HARRY R. LOCKE, M.D.; W. E. HATHAWAY, M.D.; FREDERIC FEILER, M.D.; DONALD L. DAWSON, M.D.
This content is PDF only. Please click on the PDF icon to access.
To the editor: Since 1967 several cases of a mild to moderately severe bleeding disorder associated with a platelet functional defect have been described (1-5). This disorder has been called "failure to release ADP [adenosine 5′-diphosphate]" and is characterized by normal coagulation studies, normal platelet counts, variable prolongation of the bleeding time, poor platelet retention in glass-bead filters (platelet adhesivity), and decreased aggregation of platelets by collagen and epinephrine. Platelet aggregation by exogenous adenosine 5′-diphosphate is usually normal.
Our report describes an additional case and documents correction of the defect by platelet transfusions during a surgical procedure.
The patient, a
LOCKE HR, HATHAWAY WE, FEILER F, et al. Preoperative Correction of a Platelet Functional Disorder. Ann Intern Med. 1973;78:972–973. doi: https://doi.org/10.7326/0003-4819-78-6-972
Download citation file:
Published: Ann Intern Med. 1973;78(6):972-973.
Copyright © 2020 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use