PETER J. RAVENSCROFT, M.B.
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To the editor: Dr. Klinenberg suggests in the January UCLA Conference (Ann Intern Med 78:99-111, 1973) that abnormalities in urate binding may be significant in the pathogenesis of urate deposition disease. The rationale for this statement appeared to be supported by in vitro binding studies performed at 4°C. In the original report of this in vitro binding method (1) the effect of temperature on urate binding at 37°C suggests that the binding of urate in vivo is likely to be insignificant, and this conclusion has recently been supported by Farrell, Popovich, and Babb (2), who studied pure uric acid rather
RAVENSCROFT PJ. Urate Binding. Ann Intern Med. 1973;79:140–141. doi: https://doi.org/10.7326/0003-4819-79-1-140_2
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Published: Ann Intern Med. 1973;79(1):140-141.
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