MOHINDER P. SAMBHI, M.D., Ph.D.; MILTON G. CRANE, M.D., Ph.D.; JACQUES GENEST, M.D., F.A.C.P., F.R.C.P.
Patients with benign essential hypertension in the early uncomplicated stage show several deviations from normal in their renal and adrenal hormonal systems. Levels of plasma aldosterone and progesterone and the secretion rate of 18-hydroxy-11-deoxycorticosterone are shown to be increased, and the metabolic clearance rate of aldosterone is shown to be decreased in these patients. Also, in vitro, the plasma, with added homologous renin, generated angiotensin at rates much higher than normal. Conflicting evidence is presented on plasma aldosterone measurements, including age-dependent decreases in plasma renin and aldosterone. The significance of these findings in pathogenesis of essential hypertension is discussed.
SAMBHI MP, CRANE MG, GENEST J. Essential Hypertension: New Concepts About Mechanisms. Ann Intern Med. ;79:411–424. doi: 10.7326/0003-4819-79-3-411
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Published: Ann Intern Med. 1973;79(3):411-424.
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