GERMÁN RAMÍREZ, M.D.; WILLIAM JUBIZ, M.D.; CHARLEY F. GUTCH, M.D., F.A.C.P.; H. ALLAN BLOOMER, M.D., F.A.C.P.; RICHARD SIEGLER, M.D.; WILLEM J. KOLFF, M.D.
Fifty-three patients with renal failure on chronic hemodialysis were screened for the presence of goiter. Thirty-one had enlarged thyroid glands, a prevalence of goiter of 58% not previously reported. Thyroid function studies showed low 131I uptakes, low serum thyroxine and normal serum triiodothyronine and thyrotrophic hormone levels. Serum concentrations of thyroxine-binding globulin were normal; serum albumin concentration was only slightly reduced. Administration of synthetic thyrotrophin-releasing hormone was followed by a rise in serum thyrotrophin and triiodothyronine levels. The cause of the goiter is not known. The possibility that goitrogenic substances are involved is discussed.
RAMÍREZ G, JUBIZ W, GUTCH CF, et al. Thyroid Abnormalities in Renal Failure: A Study of 53 Patients on Chronic Hemodialysis. Ann Intern Med. 1973;79:500–504. doi: 10.7326/0003-4819-79-4-500
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Published: Ann Intern Med. 1973;79(4):500-504.
Endocrine and Metabolism, Nephrology, Renal Replacement Therapy, Thyroid Disorders.
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