BOY FRAME, M.D., F.A.C.P.; CHARLES E. JACKSON, M.D., F.A.C.P.; WILLIAM A. REYNOLDS, M.D.; JAMES E. UMPHREY, M.D.
The clinical features of vitamin A toxicity in a 7-year-old boy, a 16-year-old boy, and a 46-year-old man included vague skeletal pains and hypercalcemia. Experimental and clinical evidence indicates that hypervitaminosis A can cause bony resorption as well as periosteal calcification. Ingestion of excessive amounts of vitamin A should be considered in the differential diagnosis of hypercalcemia. Vitamin A preparations containing more than the minimum daily requirement for an adult (5000 units) per dose should be dispensed only by prescription.
FRAME B, JACKSON CE, REYNOLDS WA, et al. Hypercalcemia and Skeletal Effects in Chronic Hypervitaminosis A. Ann Intern Med. 1974;80:44–48. doi: https://doi.org/10.7326/0003-4819-80-1-44
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Published: Ann Intern Med. 1974;80(1):44-48.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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