EMMET B. KEEFFE, M.D.; EMIL J. BARDANA JR., M.D., F.A.C.P.; RONALD J. HARBECK, Ph.D.; BERNARD PIROFSKY, M.D., F.A.C.P.; RONALD I. CARR, M.D., Ph.D.
A patient with systemic lupus erythematosus presented with meningitis. All attempts to isolate a microorganism were unsuccessful. Hypocomplementemia, associated with antibodies to deoxyribonucleic acid (DNA) and DNA:anti-DNA complexes, was found in serum and cerebrospinal fluid. We found a striking correlation among the presence of these complexes, activity of disease, and symptomatic improvement from corticosteroids. These findings suggest that lupus meningitis is a distinct, immunologically mediated clinical entity.
KEEFFE EB, BARDANA EJ, HARBECK RJ, et al. Lupus Meningitis: Antibody to Deoxyribonucleic Acid (DNA) and DNA:anti-DNA Complexes in Cerebrospinal Fluid. Ann Intern Med. 1974;80:58–60. doi: 10.7326/0003-4819-80-1-58
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Published: Ann Intern Med. 1974;80(1):58-60.
Lupus Erythematosus, Rheumatology.
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