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Clinical psychopharmacology has entered a second generation, with two distinctive trends emerging:  a harder look beyond efficacy demonstrations to the social and side-effect costs of the widespread and long-term use of antianxiety and antipsychosis drugs, and  more need for clinical information on therapeutic response differences in patient subgroups and for pharmacologic information on metabolism and pharmacokinetics. In this book, for example, variations in the therapeutic responses to antidepressant drugs in many studies are suggested to be primarily a matter of incomplete differentiation of patient subgroups. Similarly, the infrequently demonstrated superiority of antianxiety drugs over placebos is interpreted as
Clinical Use of Psychotherapeutic Drugs.. Ann Intern Med. 1974;80:124. doi: 10.7326/0003-4819-80-1-124_2
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Published: Ann Intern Med. 1974;80(1):124.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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