GARY L. GRAMMENS, PH.D., M.D.; ROBERT T. BRECKENRIDGE, M.D., F.A.C.P.
To the editor: Several reports of thromboembolic complications after the use of factor IX concentrates have recently appeared (1-3). These reports have prompted us to survey our experience with the products during the past 4 years1.
During this period, 1984 vials of Konȳne® (Cutter Laboratories, Berkeley, California) and 57 vials of Proplex® (Hyland Laboratories, Costa Mesa, California) were used in treating 15 patients with Christmas disease (factor IX deficiency), (Table 1). Most of the treatment episodes required only outpatient care, with the use of small amounts of concentrate for short periods; however, there were seven events in which patients required
GRAMMENS GL, BRECKENRIDGE RT. Complications with Christmas Factor (Factor IX) Concentrates. Ann Intern Med. ;80:666–667. doi: 10.7326/0003-4819-80-5-666
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Published: Ann Intern Med. 1974;80(5):666-667.
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