R. D. POWELL, M.D.; A. L. LARSON, M.D.; R. I. HENKIN, M.D.
A procedure for biopsy and light microscopic evaluation of the nasal mucous membrane was developed. It was used in 15 patients with Sjögren's syndrome, and the results compared with those of a similar procedure applied to the lip. Results indicated that the pathological changes found in the nose were similar to those found in the lip. The most characteristic pathological feature in the nose and in the lip was periglandular infiltration by chronic inflammatory cells with glandular atrophy. These changes in the nose have been observed only in patients with Sjögren's syndrome. Biopsy of the nasal mucous membrane is a simple method that can be used repeatedly and has little morbidity. As such, it is a useful method to aid in the diagnosis and evaluation of therapy of Sjögren's syndrome.
POWELL RD, LARSON AL, HENKIN RI. Nasal Mucous Membrane Biopsy in Sjögren's Syndrome: A New Diagnostic Technique. Ann Intern Med. 1974;81:25–31. doi: 10.7326/0003-4819-81-1-25
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Published: Ann Intern Med. 1974;81(1):25-31.
Pulmonary/Critical Care, Rheumatology.
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