LAWRENCE M. SLOTKOFF, M.D., Ph.D., F.A.C.P.
Prostaglandin A1 (PGA1) causes vasodilation, natriuresis, and is inotropic. Its onset of action is rapid. PGA1 was administered, in doses ranging from 0.6 to 2.4 µg/kg body weight · min, to a woman with severe hypertension in congestive heart failure. The infusion was continued for more than 2 hours. During that time her blood pressure fell from 220/110 to 100/60 mm Hg, a diuresis of 18 ml/min was reached, and within several hours symptoms and signs of congestive heart failure cleared. These effects were dose-related. Within minutes after cessation of the PGA1 infusion, blood pressure and renal functions returned to pretreatment levels. Peripheral renin levels were low and did not rise significantly in response to PGA1, probably because of previously administered adrenergic blockers. Despite previous sympathetic blockade and low renin levels, PGA1 had all the previously reported effects on renal function. This case illustrates a possible therapeutic use for PGA1 in hypertensive crisis.
SLOTKOFF LM. Prostaglandin A1 in Hypertensive Crisis. Ann Intern Med. ;81:345–347. doi: 10.7326/0003-4819-81-3-345
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Published: Ann Intern Med. 1974;81(3):345-347.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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