LEONARD S. GOLDBERG, M.D., F.A.C.P.; RODNEY BLUESTONE, M.B., M.R.C.P.; E. RICHARD STIEHM, M.D.; PAUL I. TERASAKI, Ph.D.; RICHARD H. WEISBART, M.D.
Many investigators consider pernicious anemia an autoimmune disease. Cellular and humoral immunity to gastric antigens, particularly intrinsic factor, has been found in most patients with this disorder. Although a cause-effect relation between these immune abnormalities and the disease process is unproved, current evidence suggests that cell-mediated immune mechanisms may be responsible for the atrophic gastritis in pernicious anemia. Like several other presumed autoimmune disorders, this disease occurs with increased frequency in immunodeficiency states; this association raises the possibility that autoimmunity may be the consequence of a deficient rather than a heightened immune response. Thus, pernicious anemia appears to represent an excellent model to study the interrelations between autoimmune disease, cellular and humoral immune mechanisms, and immunodeficiency states.
GOLDBERG LS, BLUESTONE R, STIEHM ER, et al. Human Autoimmunity, with Pernicious Anemia as a Model. Ann Intern Med. 1974;81:372–380. doi: 10.7326/0003-4819-81-3-372
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Published: Ann Intern Med. 1974;81(3):372-380.
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