VICTOR GUREWICH, M.D., F.A.C.P.; BOGUSLAW LIPINSKI, PH.D.
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To the editor: The report of Klein and Bell (Ann Intern Med 80:477-481, 1974) of disseminated intravascular coagulation occurring during heparin therapy is an important reminder of the inadequate state of our knowledge of this important syndrome. The need for a controlled study of the use of heparin in this syndrome may indeed be evident, as they state, but first it will be necessary to standardize our methods for controlling heparin therapy.
Clotting time is the accepted and rational guide to heparin dosage in venous thromboembolic disease, but it may be an inadequate and meaningless guide in disseminated intravascular coagulation.
GUREWICH V, LIPINSKI B. Heparin Dosage and Clotting Time. Ann Intern Med. ;81:567–568. doi: 10.7326/0003-4819-81-4-567
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Published: Ann Intern Med. 1974;81(4):567-568.
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