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During its heyday in the 1950s, Han Selye's proposal of the "General Adaptation Syndrome" as a response pattern to "stress" provoked intense controversy, still unresolved after 20 years of research, argument, and counterargument. The ardor of this contention has largely died away. General adaptation syndrome (G-A-S) theory describes a nonspecific physiologic response to "stress," a response presumably mediated via the hypothalamic-pituitary-adrenal axis. Further, Selye defined three sequential stages characteristic of the organism's response to on-going "stress": "alarm" (a period of decreased resistance on immediate exposure to a stressor), "increased resistance" (a period during which the organism presents an enhanced resistance
Stress Without Distress.. Ann Intern Med. ;81:716. doi: 10.7326/0003-4819-81-5-716_1
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Published: Ann Intern Med. 1974;81(5):716.
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