RICHARD J. HAVEL, M.D.
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The disorder most commonly called "type III hyperlipoproteinemia," also referred to as "broad beta," "floating beta disease," or "dysbetalipoproteinemia," has been of great fascination to investigators of the genetically determined disorders of lipid transport in the blood. This fascination relates both to its distinctive clinical features and to the unique very low density lipoprotein (VLD lipoprotein) that accumulates in blood plasma of affected individuals. The reports from Seattle and Bethesda in this issue (pp. 141-174) provide improved criteria for diagnosing the presence of the mutant gene as well as evidence that it may be transmitted as an autosomal Mendelian dominant.
HAVEL RJ. Hyperlipoproteinemia: Problems in Diagnosis and Challenges Posed by the "Type III" Disorder. Ann Intern Med. ;82:273–274. doi: 10.7326/0003-4819-82-2-273
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Published: Ann Intern Med. 1975;82(2):273-274.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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