ROBERT E. PIERONI, M.D.
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To the editor: In a recent letter Siasoco, Chen, and Chang (1) reported that in patients with typhoid fever there was a statistically significant reduction in skin reactivity to purified protein derivative (PPD) as compared with normal controls matched by age, sex, and geographic location. Two explanations were offered for this difference: a transient suppression of tuberculin reactivity during typhoid fever and the possibility that persons with negative tuberculin reactions are more susceptible to this infection.
Although the latter possibility cannot be ruled out, some recent studies strongly suggest that bacterial infections can indeed suppress the tuberculin response, as well
PIERONI RE. Bacterial Infection and Tuberculin Reactivity. Ann Intern Med. ;82:283–284. doi: 10.7326/0003-4819-82-2-283_2
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Published: Ann Intern Med. 1975;82(2):283-284.
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