ELIOT J. PEARLMAN, M.D., MAJ, MC; ANTHONY P. HALL, M.D., F.A.C.P., COL, MC
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To the editor: Permit us to comment tardily on the article "Chemoprophylaxis of Malaria for Travelers" (Ann Intern Med 81:219-224, 1974). Dr. Barrett-Connor is wrong in her summation that weekly chloroquine and primaquine and daily dapsone is the best prophylaxis against chloroquine-resistant falciparum malaria. It is illogical because she is recommending chloroquine for chloroquine-resistance. Would she recommend chloramphenicol for chloramphenicol-resistant typhoid? The most promising compounds appear to be the combinations of dihydrofolate reductase inhibitors with a sulfonamide or sulfone for the chemosuppression of chloroquine-resistant falciparum malaria and vivax malaria (1-4).
Thanh, Huan, and Tinh (3) showed in a 3-month study
PEARLMAN EJ, HALL AP. Prevention of Chloroquine-Resistant Falciparum Malaria. Ann Intern Med. ;82:590–591. doi: 10.7326/0003-4819-82-4-590
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Published: Ann Intern Med. 1975;82(4):590-591.
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