JOHN L. ABRUZZO, M.D.
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The paper by Dr. Hunder and colleagues in this issue, "Daily and Alternate-Day Corticosteroid Regimens in Treatment of Giant Cell Arteritis" (p. 613), reports a study that directly compared alternate-day prednisone therapy with a daily dose regimen, in randomly assigned groups. Their findings reaffirm the effectiveness of daily steroid therapy in giant cell arteritis, but the value of alternate-day prednisone therapy is less clear, and the results should not be extrapolated too far. The 90-mg dose of prednisone given once every other morning was clearly less effective than 15 mg given every 8 hours or 45 mg given once daily.
ABRUZZO JL. Alternate-Day Prednisone Therapy. Ann Intern Med. ;82:714. doi: 10.7326/0003-4819-82-5-714_1
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Published: Ann Intern Med. 1975;82(5):714.
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