DONATO ALARCÓN-SEGOVIA, M.D., F.A.C.P.; JORGE C. ALCOCER, M.D.
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To the editor: During an episode of typhoid fever, a patient developed transient proteinuria, microscopic hematuria, as well as urinary hyaline and granular casts and pericarditis. Concurrent low complement levels suggested that these unusual manifestations were due to immune-complex disease involving Salmonella antigens.
A 23-year-old man became suddenly ill with diarrhea, vomiting, and fever. When admitted 7 days latter he had a temperature of 39 °C, the spleen tip was palpable, and on proctoscopic examination the mucosa was friable and hemorrhagic. Urinalysis showed proteinuria of 3.25 g/litre and the sediment contained erythrocytes as well as hyaline and granular casts. A
ALARCÓN-SEGOVIA D, ALCOCER JC. Immune-Complex Disease in Typhoid Fever. Ann Intern Med. 1975;82:720–721. doi: https://doi.org/10.7326/0003-4819-82-5-720_2
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Published: Ann Intern Med. 1975;82(5):720-721.
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