STEWART A. METZ, M.D.
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To the editor: The recent paper by Samaan and colleagues (Ann Intern Med 82:205-207, 1975) and the concomitant editorial by Rosen and Weintraub (pp. 274-276) were interesting, but they foster a recent tendency to muddle the distinction between the phenomenon of multiple endocrine neoplasia with that of ectopic hormone production and so to infer a common pathophysiology.
In recent years, the concept that there is no discernible pattern to ectopic production of hormones by tumors has been largely, and I believe correctly, supplanted by the bias that there is a discernible and often predictable pattern to this phenomenon (1, 2,
METZ SA. Ectopic Hormones from Tumors. Ann Intern Med. 1975;83:117–118. doi: https://doi.org/10.7326/0003-4819-83-1-117
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Published: Ann Intern Med. 1975;83(1):117-118.
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