HENRIETTE LACKNER, M.D., M.R.C.P.; SIMON KARPATKIN, M.D.
Seventy-five consecutive patients with normal platelet counts were investigated for "easy bruising." All had a normal coagulation profile, and all except four were women. None were on aspirin or other antiplatelet agents. Two specific groups could be delineated. In type I (44 patients, mean age, 35), platelet function was normal to supranormal. Megathrombocyte number was elevated in 60% of patients and correlated with the presence of antiplatelet antibody in 30% of patients. In type II (31 patients, mean age, 34), platelet function was abnormal: impaired epinephrine aggregation (primary and secondary wave) in 97%, impaired connective tissue aggregation in 77%, and impaired ADP aggregation in 42%. Megathrombocyte number was elevated in 71%, and antiplatelet antibody was present in 38% of patients. The "easy bruising" syndrome can be differentiated into two categories: type I, in which a platelet abnormality is unlikely, and type II, in which a platelet abnormality exists. Elevated incidence of antiplatelet antibody in both groups suggests a possible autoimmune cause.
LACKNER H, KARPATKIN S. On the "Easy Bruising" Syndrome with Normal Platelet Count: A Study of 75 Patients. Ann Intern Med. 1975;83:190–196. doi: 10.7326/0003-4819-83-2-190
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Published: Ann Intern Med. 1975;83(2):190-196.
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