CHANG SHIM, M.D.; M. HENRY WILLIAMS Jr., M.D.
We studied 18 patients with moderate to severe asthma for cardiac response to repeated doses of isoproterenol aerosol. In only 1 patient was there a significant increase in heart rate immediately after inhalation of isoproterenol aerosol, and it lasted only for 1 minute. In 2 patients increased heart rate was either due to breathholding or to the propellant in the aerosol. There was no cumulative effect on heart rate. Arrhythmias did not develop at any time despite repeated doses of aerosol every 5 to 20 minutes. Peak expiratory flow rate increased 5 minutes after the first dose, and it increased even further after repeated doses; at no time did it decrease after repeated doses.
SHIM C, WILLIAMS MH. Cardiac Response to Repeated Doses of Isoproterenol Aerosol. Ann Intern Med. ;83:208–211. doi: 10.7326/0003-4819-83-2-208
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Published: Ann Intern Med. 1975;83(2):208-211.
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