CHARLES H. HALSTED, M.D., F.A.C.P.; JOHN W. ROWE, M.D.
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Gluten-sensitive enteropathy has been found in association with several diseases including dermatitis herpetiformis, diabetes mellitus, and immunoglobulin A deficiency. The HLA-8 histocompatibility antigen is present in 80% of patients with gluten-sensitive enteropathy compared with 20% of the normal population (1).
A patient with Fabry's disease (glycosphingolipidosis) was found to have gluten-sensitive enteropathy and the HLA-8 antigen. Review of the literature indicates that abnormal intestinal function is not infrequent in Fabry's disease although intestinal malabsorption has not been previously documented.
A 59-year-old white man presented with scrotal angiokeratomas. He had been thin all his adult life and had experienced occasional abdominal
HALSTED CH, ROWE JW. Occurrence of Celiac Sprue in a Patient with Fabry's Disease. Ann Intern Med. ;83:524–525. doi: 10.7326/0003-4819-83-4-524
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Published: Ann Intern Med. 1975;83(4):524-525.
Celiac Disease and Malabsorption, Encephalopathy, Gastroenterology/Hepatology, Neurology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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