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The association of particular human leukocyte (transplantation) antigens with specific human diseases is one of the most exciting discoveries in recent clinical research. Nevertheless, the explanations for these associations remain purely speculative. One of the 10 articles in this issue surveys all the associations described to date. Some others concentrate on a few illustrative examples, for example, multiple sclerosis, Hodgkin's disease, systemic lupus erythematosus, and endocrine diseases. Of the 4 chapters dealing with background experimental studies, the paper, "Disease Predisposition Immune Responsiveness and the Fine Structure of the HLA Supergene," by van Rood and colleagues provides an especially good example
HL-A and Disease.. Ann Intern Med. 1975;83:590–591. doi: https://doi.org/10.7326/0003-4819-83-4-590_3
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Published: Ann Intern Med. 1975;83(4):590-591.
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