JOHN L. DECKER, M.D., F.A.C.P.; JOHN H. KLIPPEL, M.D.; PAUL H. PLOTZ, M.D.; ALFRED D. STEINBERG, M.D.
Thirty-eight patients with diffuse glomerulonephritis of systemic lupus erythematosus were randomly assigned to add cyclophosphamide, azathioprine, or nothing to low-dose corticosteriod treatment and have been followed for a mean of 2⅓ years thereafter. Of the 11 patients with unfavorable outcomes (8 deaths and 3 beginning hemodialyses), 2 occurred on cyclophosphamide, 4 on azathioprine, and 5 on prednisone only. Deaths due to infection occurred on the cytotoxics, while deaths ascribed to central nervous system lupus erythematosus occurred exclusively on prednisone only. Gradual deterioration of renal function was observed in all three groups, most frequently on prednisone only. Undesirable events, some due to drugs, were observed. At the time of reporting, the cytotoxic agents seemed to add marginally to the control of the disease; other treatment schedules should be evaluated.
DECKER JL, KLIPPEL JH, PLOTZ PH, STEINBERG AD. Cyclophosphamide or Azathioprine in Lupus Glomerulonephritis: A Controlled Trial: Results at 28 Months. Ann Intern Med. ;83:606–615. doi: 10.7326/0003-4819-83-5-606
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Published: Ann Intern Med. 1975;83(5):606-615.
Autoimmune Kidney Disease, Lupus Erythematosus, Nephrology, Rheumatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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