FREDERICK P. LI, M.D.; JOSEPH F. FRAUMENI JR., M.D., F.A.C.P.
This content is PDF only. Please click on the PDF icon to access.
In 1969, we described in 4 families (A through D) a syndrome of soft-tissue sarcomas, breast cancer, and other neoplasms affecting children and young adults (1). We present the findings on follow-up of families A, B, and C. Family D has been lost to contact.
During the past 7 years, 8 of approximately 50 surviving members of the three families have been diagnosed with new malignancies. In Family C breast cancer developed in both sisters of a pair of male siblings with childhood sarcoma (Figure 1). Patient IV-3 had adenocarcinoma of the right breast at age 32 years, while patient
LI FP, FRAUMENI JF. Familial Breast Cancer, Soft-Tissue Sarcomas, and Other Neoplasms. Ann Intern Med. ;83:833–834. doi: 10.7326/0003-4819-83-6-833_2
Download citation file:
Published: Ann Intern Med. 1975;83(6):833-834.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use