LAWRENCE RAMSAY, M.R.C.P. (UK); DAVID LEVINE, M.R.C.P. (UK); JOHN SHELTON, B.SC.; ROBERT BRANCH, M.R.C.P. (UK); RICHARD AUTY, M.R.C.P. (UK)
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To the editor: We read with interest about the increased prevalence of hyperuricaemia and gouty arthritis in patients with Bartter's syndrome (Ann Intern Med 83:56-59, 1975), but the authors' conclusions that systemic alkalosis can decrease the clearance of uric acid, and that physicians should be aware of this inhibitory effect of alkalosis on urate clearance, do not seem justified by the evidence presented. This evidence was obtained in a careful study of five patients with normal renal function, and the results were given in Table 2 of the paper. Systemic alkalosis was induced by substituting 100 meq sodium bicarbonate for
RAMSAY L, LEVINE D, SHELTON J, et al. Alkalosis and Urate Clearance. Ann Intern Med. 1975;83:903–904. doi: https://doi.org/10.7326/0003-4819-83-6-903
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Published: Ann Intern Med. 1975;83(6):903-904.
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