DANIEL M. KNOWLES, M.D.; MARIANNE WOLFF, M.D.
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To the editor: The "pill-associated benign hepatic neoplasms" have evoked considerable interest, as evidenced by still another report, by Stauffer and associates (Ann Intern Med 83:301-306, 1975). We believe that several points raised in that report do, however, require clarification.
Stauffer and colleagues consider as a homogeneous group all of the "pill-associated hepatic neoplasms," referring to the occurrence in young women using oral contraceptives as a syndrome. This melée consists of at least two distinct clinicopathologic entities, focal nodular hyperplasia and liver cell adenoma, which unfortunately have not generally been well recognized and accurately diagnosed by pathologists.
Critical histopathologic review
KNOWLES DM, WOLFF M. Systemic Contraceptives and the Liver. Ann Intern Med. ;83:907–908. doi: 10.7326/0003-4819-83-6-907
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Published: Ann Intern Med. 1975;83(6):907-908.
Gastroenterology/Hepatology, Liver Disease.
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