LEWIS M. COHEN, M.D.; KAMAL K. MITTAL, Ph.D.; FRANK R. SCHMID, M.D., F.A.C.P.; LEE F. ROGERS, M.D.; KENNETH L. COHEN, M.D.
Evidence for ankylosing spondylitis was sought by clinical, radiologic, and ophthalmologic examination in HL-A W27-positive men, aged 18 or older, selected from a tissue-donor population. Back pain of 3 months' duration or longer (P < 0.05), back stiffness, restricted lumbar flexion and chest expansion, sacroiliac erosions (P < 0.05) and sclerosis, and ophthalmologic sequels of anterior uveitis were found more often in the 24 men of the W27 group than in a control group of 31 men lacking this antigen. Based upon accepted criteria, 3 W27 persons had definite spondylitis and an additional 3 W27 persons and one control subject had findings strongly suggestive of spondylitis (P < 0.05). This striking frequency, if extrapolated to the general population, would place approximately 1 of 4 W27-positive men at risk for this disease.
COHEN LM, MITTAL KK, SCHMID FR, et al. Increased Risk for Spondylitis Stigmata in Apparently Healthy HL-AW27 Men. Ann Intern Med. 1976;84:1–7. doi: https://doi.org/10.7326/0003-4819-84-1-1
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Published: Ann Intern Med. 1976;84(1):1-7.
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