FREDERICK L. GLAUSER, M.D.; WILLIAM RICHARD SMITH, M.D.; ALEX CALDWELL, M.D.; MELVIN HOSHIKO, M.D.; GEOFFREY S. DOLAN, M.D.; HAROLD BAER, M.D.; NEAL OLSHER, M.D.
Two patients experienced severe nonhemodynamic pulmonary edema following the intravenous injection of 25 and 40 mg/kg of body weight of ethchlorvynol (Placidyl⌖). The pulmonary edema cleared rapidly. Injection of Placidyl (12 to 80 mg/kg of body weight) intravenously into dogs caused acute, severe, nonhemodynamic pulmonary edema (as evidenced by markedly elevated lung weights and microscopic evidence of intra-alveolar edema), hypotension with a relative bradycardia, and a decreased cardiac output. Injection of polyethylene glycol, the vehicle in which ethchlorvynol is diluted, did not reproduce the syndrome.
GLAUSER FL, SMITH WR, CALDWELL A, et al. Ethchlorvynol (Placidyl⌖)-Induced Pulmonary Edema. Ann Intern Med. 1976;84:46–48. doi: 10.7326/0003-4819-84-1-46
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Published: Ann Intern Med. 1976;84(1):46-48.
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