JORDAN L. HOLTZMAN, M.D., PH.D.
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Neuromuscular blockade is a major toxicity of amino-glycoside antibiotics (1, 2). Yet gentamicin has only rarely been associated with blockade (3, 4). Warner and Sanders (3) reported on a patient who had 14 days of gentamicin and then a laparotomy during which he received curare. Forty-eight hours later he had respiratory arrest attributed to gentamicin neuromuscular blockade. Similarly Hall and associates (4) reported on a uremic patient who had neuromuscular blockade after tubocurarine, lidocaine, and gentamicin, suggesting an additive effect of these agents (5). We recently observed a patient with severe Parkinson's disease who on two occasions exhibited a profound
HOLTZMAN JL. Gentamicin and Neuromuscular Blockade. Ann Intern Med. ;84:55. doi: 10.7326/0003-4819-84-1-55_1
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Published: Ann Intern Med. 1976;84(1):55.
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