K. VENKATESWARA RAO, M.B., B.S.; ROBERT O. BERKSETH, M.D.; JOHN T. CROSSON, M.D.; LEOPOLDO RAIJ, M.D.; FRED L. SHAPIRO, M.D., F.A.C.P.
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Mixed connective tissue disease has been recognized as a rheumatic syndrome with features similar to those of systemic lupus erythematosus, progressive systemic sclerosis, and polymyositis, but distinguished from them by the presence of a specific antibody in high titers to an extractable nuclear antigen (1). Renal involvement was reported to be rare in this disease, and Sharp and colleagues (1) speculated that the antibody to extractable nuclear antigen was exerting protective effect. We describe here a patient with mixed connective tissue disease showing histologic evidence of immune-complex glomerulonephritis in the absence of overt clinical renal disease.
An 18-year-old girl noted
RAO KV, BERKSETH RO, CROSSON JT, et al. Immune-Complex Nephritis in Mixed Connective Tissue Disease. Ann Intern Med. 1976;84:174–175. doi: https://doi.org/10.7326/0003-4819-84-2-174
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Published: Ann Intern Med. 1976;84(2):174-175.
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