ZOLTAN ZARDAY, M.D.; ROBERT J. SOBERMAN, M.D.
Carbamazepine (Tegretol®)1 has been used by us in five patients with severe uremic neuropathy where pain was the dominating symptom. All patients were on chronic hemodialysis. They had been taking a number of oral analgesics previously (acetominophene, propoxyphene), with or without codeine, without significant relief. Carbamazepine was started with a dose of 100 mg twice daily and increased to 200-to-300 mg twice daily if necessary. All five patients reported relief of pain after 1 or 2 weeks of treatment. In no case did we have to give more than 600 mg (three tablets) a day. Other symptoms of uremic neuropathy,
ZARDAY Z, SOBERMAN RJ. Carbamazepine in Uremic Neuropathy. Ann Intern Med. ;84:296. doi: 10.7326/0003-4819-84-3-296
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Published: Ann Intern Med. 1976;84(3):296.
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