D. R. FORSDYKE, PH.D. (Cantab.)
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To the editor: Doctor Berkes and colleagues (Ann Intern Med 83:363-364, 1975) report the delayed onset of protracted hemolysis after the extracorporeal overheating of blood to 50 °C during hemodialysis. The patient's hemoglobin and hematocrit levels failed to rise after transfusion of 2 units of packed erythrocytes on the third day after the accident. The authors suggest that thermal injury to erythrocytes is the reason for the hemolysis.
An alternative hypothesis is that there may have been thermal injury to plasma proteins, such as complement components. These altered proteins might trigger delayed hemolysis both of the patient's erythrocytes and of
FORSDYKE DR. Hemolysis from Hot Dialysate. Ann Intern Med. ;84:490. doi: 10.7326/0003-4819-84-4-490_2
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Published: Ann Intern Med. 1976;84(4):490.
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