BRUCE R. GREENSPAHN, M.D.; PABLO DENES, M.D.; WILLIAM DANIEL, Ph.D.; KENNETH M. ROSEN, M.D.
We studied whether familial factors are significant in chronic bifascicular block. One hundred thirty-four first- and second-degree relatives of 44 outpatients with chronic bifascicular block were examined. These relatives were studied to ascertain the presence or absence of cardiac disease and conduction defects. A race-, age-, and sex-matched control group (age range, 18 to 65) was randomly chosen from a population of employed volunteers for comparison purposes. The study group had a significantly greater frequency of conduction defects than the control group (24/95 versus 10/95, P < 0.02). Study group members less than 18 years of age (32 patients) had a similar frequency of conduction defects when compared with patients described in the literature. In study group members older than 65 years, 5 out of 7 had conduction defects, a high frequency. In conclusion, the findings suggest an age-related familial tendency to conduction disease among relatives of patients with chronic bifascicular block.
GREENSPAHN BR, DENES P, DANIEL W, et al. Chronic Bifascicular Block: Evaluation of Familial Factors. Ann Intern Med. 1976;84:521–525. doi: 10.7326/0003-4819-84-5-521
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Published: Ann Intern Med. 1976;84(5):521-525.
Cardiology, Rhythm Disorders and Devices.
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