RALPH A. DeFRONZO, M.D.; MARTIN GOLDBERG, M.D.; F.A.C.P.; ZALMAN S. AGUS, M.D.
Four patients with chronic illnesses and stable hyponatremia and plasma hypotonicity had normal urinary diluting capacity, with excretion of > 80% of a standard water load (20 ml/kg) within 4 hours and maintenance of a urine osmolality < 100 mosmol/kg, during sustained water diuresis. Administration of a chronic salt load did not correct the hyponatremia. However, it was stabilized after treatment of the underlying medical condition. These subjects may represent a true resetting of the osmostat or a variant of the syndrome of inappropriate antidiuretic hormone secretion.
DeFRONZO RA, GOLDBERG M, AGUS ZS. Normal Diluting Capacity in Hyponatremic Patients: Reset Osmostat or a Variant of the Syndrome of Inappropriate Antidiuretic Hormone Secretion. Ann Intern Med. 1976;84:538–542. doi: https://doi.org/10.7326/0003-4819-84-5-538
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Published: Ann Intern Med. 1976;84(5):538-542.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology, Neurology.
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