ROBERT J. MASON, M.D.
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To the editor: The recent editorial, "Fibers and Fibrosis" by Bouhuys (Ann Intern Med 83:898-899, 1975), reviews the value of lung biopsy and analysis of fibers for diagnosis of selected occupational lung diseases. I wish to suggest an alternative investigative method for diseases produced by inhalation of insoluble particles (especially inorganic dusts). This method is based on the biology of alveolar macrophages and the development of recent technology for elemental analysis, and this suggestion may stimulate research. The method requires a major piece of equipment and is not a proved alternative to current clinical methods.
Alveolar macrophages ingest and store
MASON RJ. Identifying Foreign Matter in Pulmonary Macrophages. Ann Intern Med. 1976;84:614. doi: https://doi.org/10.7326/0003-4819-84-5-614_1
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Published: Ann Intern Med. 1976;84(5):614.
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