KENNETH D. BURMAN, M.D.; JOHN M. MONCHIK, M.D., F.A.C.S.; JERRY M. EARLL, M.D., F.A.C.P.; LEONARD WARTOFSKY, M.D., F.A.C.P.
Total and ionized calcium concentrations as well as parathyroid hormone levels were measured in a group of hyperthyroid persons. Ionized and total calcium levels were elevated in 21 of 45 (47%) and in 12 of 45 (27%) thyrotoxic patients, respectively. Mean ionized and total calcium levels were higher in these 45 patients than in normal persons. Using two different radioimmunoassay systems for a total of 44 determinations, mean parathyroid hormone levels were lower in thyrotoxic patients than in subjects with proved hyperparathyroidism. These data suggest that  elevations of both ionized and total calcium concentrations occur frequently in thyrotoxic patients;  ionized calcium concentrations may be elevated in a higher percentage of hyperthyroid subjects than are total calcium concentrations; and  the hypercalcemia associated with thyrotoxicosis is not associated with elevated parathyroid hormone levels.
BURMAN KD, MONCHIK JM, EARLL JM, et al. Ionized and Total Serum Calcium and Parathyroid Hormone in Hyperthyroidism. Ann Intern Med. 1976;84:668–671. doi: https://doi.org/10.7326/0003-4819-84-6-668
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Published: Ann Intern Med. 1976;84(6):668-671.
Endocrine and Metabolism, Thyroid Disorders.
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