ANDREW I. CEDERBAUM, M.D.; PHILIP M. BLATT, M.D.; HAROLD R. ROBERTS, M.D.
Prothrombin complex concentrates are used in the treatment of the congenital bleeding disorders associated with Factors II, VII, IX, and X deficiencies. They have also been extensively used to treat acquired coagulation abnormalities secondary to vitamin K deficiency, warfarin ingestion, and various types of liver disease. The reported complications of prothrombin complex concentrates administration include hepatitis, anaphylaxis, and thrombosis. This paper documents the development of disseminated intravascular coagulation in association with the administration of prothrombin complex concentrates to patients with liver disease.
CEDERBAUM AI, BLATT PM, ROBERTS HR. Intravascular Coagulation with Use of Human Prothrombin Complex Concentrates. Ann Intern Med. 1976;84:683–687. doi: 10.7326/0003-4819-84-6-683
Download citation file:
Published: Ann Intern Med. 1976;84(6):683-687.
Coagulopathies, Gastroenterology/Hepatology, Hematology/Oncology, Liver Disease.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use