CRAIG R. SMITH, M.D.; DIANE E. GRIFFIN, M.D., PH.D.; J. RICHARD GRAYBILL, M.D.
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Infection with Histoplasma capsulatum may cause chronic cavitary pulmonary disease in humans. Approximately 12% to 17% of patients with chronic pulmonary histoplasmosis have an impaired cell-mediated immune response to histoplasmin (1). Alford and Goodwin (2) have suggested that this impairment may be reversed by transfer factor. We gave 3 U of transfer factor to a patient with anergic chronic pulmonary histoplasmosis and observed transient conversion of his skin test and lymphocyte transformation index (LTI).
A 48-year-old man was well until 8 years before admission when he developed cavitary pulmonary tuberculosis. He was treated with isoniazid (INH), para-aminosalicylic acid (PAS), streptomycin,
SMITH CR, GRIFFIN DE, GRAYBILL JR. Chronic Pulmonary Histoplasmosis: Improved Lymphocyte Response with Transfer Factor. Ann Intern Med. 1976;84:708–709. doi: https://doi.org/10.7326/0003-4819-84-6-708
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Published: Ann Intern Med. 1976;84(6):708-709.
Infectious Disease, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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