DAVID W. GOLDE, M.D., F.A.C.P.; SHIRLEY G. QUAN, M.A.; MARTIN J. CLINE, M.D., F.A.C.P.
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Hairy cell leukemia, or leukemic reticuloendotheliosis, is a well-defined clinical entity characterized by peripheral blood cytopenias and diffuse infiltration of the bone marrow and spleen by neoplastic cells with hairlike projections (1). The hairy cell has a unique morphology and may be identified easily by the histochemical demonstration of large amounts of tartrate-resistant acid phosphatase (2). It is important to differentiate this condition from other hematopoietic malignancies as the treatment of choice appears to be splenectomy rather than chemotherapy (1, 2).
There has been considerable divergence of opinion regarding the nature of the neoplastic cell. Substantial evidence has accumulated for
GOLDE DW, QUAN SG, CLINE MJ. Hairy Cell Leukemia: In-Vitro Culture Studies. Ann Intern Med. ;85:78–79. doi: 10.7326/0003-4819-85-1-78
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Published: Ann Intern Med. 1976;85(1):78-79.
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