GARY R. EPLER, M.D.; M. ANEES KHAN, M.D.
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To the editor: In the paper by Schatz and colleagues on the prevalence of tuberculosis in a steroid-treated asthmatic population (Ann Intern Med 84:261-265, 1976), they conclude that long-term use of corticosteroids in this clinical setting does not increase the risk of active tuberculosis and that such patients, therefore, should not receive isoniazid chemoprophylaxis.
The authors seem to convey the impression that the risk of tuberculosis was ascertained in 132 patients over 620 corticosteroid years. In fact, only the intermediate-strength tuberculin reactors representing 185 patient years (37 patients with mean follow-up of 5.1 years) were actually subjected to this risk
EPLER GR, KHAN MA. Tuberculosis and Isoniazid in Steroid-Treated Asthmatic Patients. Ann Intern Med. ;85:129–131. doi: 10.7326/0003-4819-85-1-129
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Published: Ann Intern Med. 1976;85(1):129-131.
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