WILLIAM R. BELL, M.D., F.A.C.P.; PETER A. TOMASULO, M.D.; BARBARA M. ALVING, M.D.; THOMAS P. DUFFY, M.D.
In a group of 52 patients receiving continuous intravenous heparin, 16 developed thrombocytopenia (platelets < 100 000/mm3). Ten of the 16 patients who had thrombocytopenia had elevated titers of fibrinogen-fibrin degradation products, and five of these 10 patients also had a reduction in plasma fibrinogen. The abnormalities disappeared after the heparin preparation was discontinued. These occurrences could not be attributed to drugs other than heparin, to the dose of heparin administered, or to prior exposure to heparin. The mechanism by which the heparin preparation may induce these changes is not known.
BELL WR, TOMASULO PA, ALVING BM, et al. Thrombocytopenia Occurring During the Administration of Heparin: A Prospective Study in 52 Patients. Ann Intern Med. 1976;85:155–160. doi: 10.7326/0003-4819-85-2-155
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Published: Ann Intern Med. 1976;85(2):155-160.
Hematology/Oncology, Platelet Disorders.
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