JOHN W. LITTLE, M.D.; WILLIAM J. HALL, M.D., F.A.C.P.; R. GORDON DOUGLAS Jr, M.D., F.A.C.P.; RICHARD W. HYDE, M.D.; DONNA M. SPEERS, B.S.
Amantadine HCl administration has resulted in accelerated resolution of influenza A illness. Prolonged abnormalities in pulmonary function have been described in uncomplicated influenza A. To study the effect of amantadine on these changes, we evaluated young adults with documented natural influenza A with clear chest examinations and X rays. Subjects received placebo or amantadine in random, doubleblind fashion. Physiologic studies included maximal expiratory flow volume curves with air and helium-oxygen mixtures. Air flow rates were unchanged in all subjects throughout. Initially, both groups showed comparable decreases in mean helium-oxygen maximal expiratory flow rates. The amantadine group showed accelerated physiologic improvement: significant increase in helium-oxygen flow rates occurred within 7 days (P < 0.05). The rate of improvement in the helium-oxygen flow rates in the placebo group was not statistically significant. These studies confirm peripheral airways dysfunction after uncomplicated influenza A and suggest that amantadine is associated with accelerated resolution of this dysfunction.
LITTLE JW, HALL WJ, DOUGLAS RG, et al. Amantadine Effect on Peripheral Airways Abnormalities in Influenza: A Study in 15 Students with Natural Influenza A Infection. Ann Intern Med. 1976;85:177–182. doi: https://doi.org/10.7326/0003-4819-85-2-177
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Published: Ann Intern Med. 1976;85(2):177-182.
Infectious Disease, Pulmonary/Critical Care.
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