APOSTOLOS G. VAGENAKIS, M.D.; KEVIN DOLE, M.D.; LEWIS E. BRAVERMAN, M.D., F.A.C.P.
Enlargement of the pituitary gland associated with primary hypothyroidism was observed in two patients. Serum thyroid-stimulating hormone (TSH) concentration and the TSH response to thyrotropin-releasing hormone were increased in both. Other pituitary function tests were subnormal in both patients, suggesting that a thyrotroph pituitary tumor was present that compromised the other pituicytes. The presence of a pituitary tumor secondary to primary hypothyroidism and resulting pituitary failure should be considered in all patients with long-standing primary hypothyroidism.
VAGENAKIS AG, DOLE K, BRAVERMAN LE. Pituitary Enlargement, Pituitary Failure, and Primary Hypothyroidism. Ann Intern Med. ;85:195–198. doi: 10.7326/0003-4819-85-2-195
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Published: Ann Intern Med. 1976;85(2):195-198.
Endocrine and Metabolism, Neurology, Pituitary Disorders, Thyroid Disorders.
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