STEPHEN H. HINDMAN, M.D.; CLIFTON R. GRAVELLE, M.S.; BERT L. MURPHY, M.S.; DANIEL W. BRADLEY, Ph.D.; WILLIAM R. BUDGE, M.D.; JAMES E. MAYNARD, M.D., Ph.D.
Sera of 103 carriers of hepatitis B surface antigen were assayed for e-antigen and anti-e. Twenty-four were e-antigen-positive, 31 anti-e-positive, and 48 had neither detectable (e-negative). Aminotransferases were elevated in 75% of the e-antigen-positive carriers compared with 25% of e-negative carriers (P < 0.001) and 13% of anti-e-positive carriers (P < 0.001). Serum DNA polymerase activity was significantly higher in the e-antigen-positive carriers than in carriers without e-antigen. Dane particles were shown in 10 of 12 carriers with e-antigen, compared with one of 12 e-negative carriers (P < 0.0003) and none of 12 anti-e-positive carriers (P < 0.00003). These results suggest that ongoing hepatitis B viral replication is more active in e-antigen-positive carriers than in carriers without e-antigen, a finding that may help explain the high prevalence of chronic active hepatitis described in these individuals.
HINDMAN SH, GRAVELLE CR, MURPHY BL, et al. "e" Antigen, Dane Particles, and Serum DNA Polymerase Activity in HBSAg Carriers. Ann Intern Med. 1976;85:458–460. doi: 10.7326/0003-4819-85-4-458
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Published: Ann Intern Med. 1976;85(4):458-460.
Gastroenterology/Hepatology, Infectious Disease, Liver Disease, Prevention/Screening.
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