JOHN A. PENNER, M.D.
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To the editor: I write with reference to "Intravascular Coagulation With Use of Human Prothrombin Complex Concentrates," the paper by Cederbaum, Blatt, and Roberts in the June issue (Ann Intern Med 84:683-687, 1976). Although I quite agree with Dr. Cederbaum and co-authors' conclusions that the prothrombin complex product should not be used in nonhemophilic patients when therapeutic alternatives are available, the doses administered to the patients cited in their paper were considerably higher than what is ordinarily recommended by the manufacturer for replacement therapy in hemophilia. The doses described are similar to those used to initiate disseminated intravascular coagulation in
PENNER JA. Prothrombin Complex Concentrates and Coagulation. Ann Intern Med. ;85:531–532. doi: 10.7326/0003-4819-85-4-531
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Published: Ann Intern Med. 1976;85(4):531-532.
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