LEE B. REICHMAN, M.D., M.P.H., F.A.C.P.; WAYMAN C. LATTIMORE, M.D.; REYNARD J. MCDONALD, M.D.
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To the editor: In a recent paper in this journal, Schatz and associates (1) suggest that routine isoniazid preventive therapy for asthmatics on steroids be dispensed with. While their aim is laudable in that the actual relation of steroid treatment to tuberculous disease does need to be proved and quantified, the data acquisition, study design, control, and interpretation of data do not provide an adequate basis for their conclusions or recommendations.
Asthmatics were skin tested by the Mantoux technique with self-reading. Self-reading, however, has never been validated for the Mantoux test. The authors state, "Although this approach may not be
REICHMAN LB, LATTIMORE WC, MCDONALD RJ. Asthma, Steroid Therapy, Isoniazid. Ann Intern Med. ;85:538–539. doi: 10.7326/0003-4819-85-4-538
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Published: Ann Intern Med. 1976;85(4):538-539.
Asthma, Pulmonary/Critical Care.
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