A. S. RUSSELL, M.D., F.R.C.P.(C); B. C. LENTLE, M.D., F.R.C.P.(C), D.M.R.D.; J. S. PERCY, M.D., F.R.C.P.(Edin)(C); F. I. JACKSON, M.D., Ch.B., C.R.C.P.(C)
HLA-B27 is a transplantation antigen found in a high proportion of patients with ankylosing spondylitis. Recently, an association has been shown to exist between HLA-B27 and acute uveitis, even in the absence of ankylosing spondylitis. We have examined the HLA antigen profile of 45 patients with acute nongranulomatous anterior uveitis and have confirmed this relation. In addition, using 99mtechnetium stannous pyrophosphate we have been able to demonstrate abnormal bone scan in 19 of 30 patients studied. Such abnormalities are limited to the sacroiliac joints but are otherwise the same as those seen in overt ankylosing spondylitis. Seven of the 19 patients did not have HLA-B27. These factors suggest that acute anterior uveitis may often represent a manifestation of a spondylitic diathesis even in the complete absence of any suggestive symptomatic or radiologic change and, in some cases, even though the antigenic marker HLA-B27 may be absent.
RUSSELL AS, LENTLE BC, PERCY JS, JACKSON FI. Scintigraphy of Sacroiliac Joints in Acute Anterior Uveitis: A Study of Thirty Patients. Ann Intern Med. 1976;85:606–608. doi: 10.7326/0003-4819-85-5-606
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Published: Ann Intern Med. 1976;85(5):606-608.
Infectious Disease, Rheumatology.
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