HENRY R. LESESNE, M.D.; JOHN E. MORGAN, M.D.; PHILIP M. BLATT, M.D.; WILLIAM P. WEBSTER, D.D.S.; HAROLD R. ROBERTS, M.D.
Hepatitis is a significant complication of the treatment of hemophilia A with factor VIII concentrates. Chronic liver disease in these patients is infrequently documented in the literature. The results of percutaneous liver biopsy, under the coverage of glycine-precipitated factor VIII, in six patients with hemophilia A who had the persistence of abnormal liver-function tests for at least 6 months, are described. Three patients had chronic active hepatitis, and three had chronic persistent hepatitis. No complications were encountered as a result of the biopsy procedure. These results suggest that percutaneous liver biopsy should be considered in patients with hemophilia A with continuously abnormal liver-function tests to establish a histologic diagnosis and to guide further therapy.
LESESNE HR, MORGAN JE, BLATT PM, et al. Liver Biopsy in Hemophilia A. Ann Intern Med. 1977;86:703–707. doi: 10.7326/0003-4819-86-6-703
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Published: Ann Intern Med. 1977;86(6):703-707.
Coagulopathies, Gastroenterology/Hepatology, Hematology/Oncology, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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