JULES L. DIENSTAG, M.D.; ABDUL ALAAMA, M.D.; JAMES W. MOSLEY, M.D.; ALLAN G. REDEKER, M.D.; ROBERT H. PURCELL, M.D.
We studied serologically 45 adults who had sporadic acute viral hepatitis that was hepatitis B surface antigen (HBsAg) negative. Two cases were due to hepatitis B virus, as demonstrated by the appearance of antibody to hepatitis B core antigen. In three other patients, the serologic pattern was inconclusive. Of 40 non-B cases, 20 were type A hepatitis and 20 were non-A, non-B hepatitis. Clinically, type A and non-A, non-B hepatitis were indistinguishable; one case of fulminant disease occurred in each group. The type A cases were more frequent in young adults; non-A, non-B disease predominated in women 35 years or older. Epidemiologic backgrounds were generally similar, including illicit self-injection; but four transfusion-associated cases were limited to the non-A, non-B group. We conclude that relatively few HBsAg-negative cases are due to hepatitis B virus, and that hepatitis A virus and non-A, non-B viruses are both important in acute non-B disease.
DIENSTAG JL, ALAAMA A, MOSLEY JW, et al. Etiology of Sporadic Hepatitis B Surface Antigen-Negative Hepatitis. Ann Intern Med. 1977;87:1–6. doi: https://doi.org/10.7326/0003-4819-87-1-1
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Published: Ann Intern Med. 1977;87(1):1-6.
Gastroenterology/Hepatology, Infectious Disease, Liver Disease.
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